Smoothing rough and damaged surfaces
Damaged joint cartilage has an extremely limited ability to heal itself, and also produces enzymes that may actually make the damage worse.
By smoothing out the loose fragments, the destructive cascade may lessen.
Peer-reviewed papersQuote from peer-reviewed paper:
"....Articular hyaline cartilage is extensively hydrated, but it is neither innervated nor vascularized, and its low cell density allows only extremely limited self-renewal...."
Citation: Medvedeva EV, Grebenik EA, Gornostaeva SN, Telpuhov VI, Lychagin AV, Timashev PS, Chagin AS. Repair of Damaged Articular Cartilage: Current Approaches and Future Directions. Int J Mol Sci. 2018 Aug 11;19(8):2366. doi: 10.3390/ijms19082366. PMID: 30103493; PMCID: PMC6122081.
Importing stem cells
Stem cells have the potential to transform into other specialised cells according to the tissue's need.
They may be encouraged to enter the damaged area by poking small holes into the underlying bone marrow, through which the stem cells can migrate.
Stem cells can also be cultured in a laboratory and injected back into the joint.
The marrow-stimulation technique of microfracture employs a small pick to create tiny holes through the hard base layer of the damaged area, allowing blood and the patient's own stem cells to enter the area and start the healing process.
Nanofracture is similar but uses a smaller-gauge pick.
Peer-reviewed papersQuote from peer-reviewed paper:
"....disrupting the subchondral bone integrity....is only effective for small defects, and moreover, provides relatively short-term functional improvement due to the formation of fibrocartilage rather than hyaline articular cartilage...."
Citation: Medvedeva EV, Grebenik EA, Gornostaeva SN, Telpuhov VI, Lychagin AV, Timashev PS, Chagin AS. Repair of Damaged Articular Cartilage: Current Approaches and Future Directions. Int J Mol Sci. 2018 Aug 11;19(8):2366. doi: 10.3390/ijms19082366. PMID: 30103493; PMCID: PMC6122081.
Mosaicplasty is a 1-stage technique of osteochondral implantation, where larger defects are packed with small plugs of bone and cartilage taken from a less essential part of the joint.
Quick linksAdding cultured cartilage cells
Because the cells in mature cartilage are held in suspension within a cartilage matrix, laboratory techniques are employed to extract them from healthy samples of cartilage, multiply them in culture, and then inject them back into the joint.
Techniques include Autologous Chondrocyte Implantation (ACI) and Mosaicplasty.
Autologous cartilage implantation (ACI) is a 2-stage cartilage repair procedure where cartilage cells are harvested and multiplied in a laboratory before being returned to the patient and injected behind a membrane.
Peer-reviewed papersQuote from peer-reviewed paper:
"....The challenges associated with osteochondral allograft transplantation include proper storage of the allograft, tissue availability, the possibility of an immunologic response by the recipient, and demanding surgery...."
Citation: Medvedeva EV, Grebenik EA, Gornostaeva SN, Telpuhov VI, Lychagin AV, Timashev PS, Chagin AS. Repair of Damaged Articular Cartilage: Current Approaches and Future Directions. Int J Mol Sci. 2018 Aug 11;19(8):2366. doi: 10.3390/ijms19082366. PMID: 30103493; PMCID: PMC6122081.
Forum discussions
- Does BUPA cover MACI/ACI surgery
Patients in the UK discuss payment by health insurers for cartilage repair procedures.