Bioengineered scaffolds

Written by Dr Sheila Strover on March 14, 2025

Bioengineered scaffolds are engineered structures designed to encourage the ingrowth of living cells and be implanted into the body.

Types of bioengineered scaffold

This is a very active field of research and development, and the main groups of materials include -

  • Synthetic scaffolds, eg polyurethane
  • Hydrogel scaffolds, eg synthetic materials such as poly N-isopropyl acrylamide, or natural materials such as alginate.
  • Extracellular matrix (ECM) component scaffolds, formed primarily from a macromolecule abundant in native matrix, eg collagen meniscus implants or hyaluronan scaffolds.
  • Tissue-derived scaffolds include processed whole tissue such as small intestinal submucosa, decellularised tissue or extracellular matrix, and silk